Endpoint Adjudication in Clinical Trials

Why an Independent Event Adjudication Committee is so Important?

An endpoint is any event that might indicate if the treatment being studied has had either an adverse or a positive effect on the condition being treated - or on the safety of the patient. Determining safety and efficacy depends on accurate assessment of endpoints based on unbiased data. The best way to ensure that accuracy is to introduce an adjudication process that will be implemented by an independent and objective endpoint committee. The Adjudication process is the best way proven to eliminate bias, increase accuracy, restore confidence in data and reduce risk to patients.
“Helps reduce the varied outcomes and events - a benefit that can be especially helpful during regulatory review” [American Heart Journal, March 2017, p 78].

However, endpoint adjudication tied to paper processes adds complexity and increases study costs especially because of the onerous and time-consuming management, handling and transfer of paper source documents. It has become clear that endpoint adjudication cannot be efficiently executed without the use of electronic adjudication technology like the Ethical eAdjudication® Solution.